From Neuroscience Research Techniques



"Without proper myelination, brain cells can’t send and receive signals correctly. New research from scientists at the University at Buffalo has identified the master switch that triggers the start of myelination in oligodendrocytes. In new work published in PNAS, the researchers searched fetal brain stem cells for transcription factors that were activated in myelin-producing oligodendrocytes but were absent in other types of brain cells. They identified the transcription factor SOX10, which told the cells to differentiate from neural progenitor cells to oligodendrocyte progenitors and ultimately into mature oligodendrocytes. The results of this work may lead to better treatments for multiple sclerosis, characterized by a loss of myelin in brain cells.



Read more: http://bit.ly/1pQJs90Journal article: Transcription factor induction of human oligodendrocyte progenitor fate and differentiation. PNAS, 2014. doi:10.1073/pnas.1408295111Image credit: centralasian/Flickr”

From Neuroscience Research Techniques

"Without proper myelination, brain cells can’t send and receive signals correctly. New research from scientists at the University at Buffalo has identified the master switch that triggers the start of myelination in oligodendrocytes. In new work published in PNAS, the researchers searched fetal brain stem cells for transcription factors that were activated in myelin-producing oligodendrocytes but were absent in other types of brain cells. They identified the transcription factor SOX10, which told the cells to differentiate from neural progenitor cells to oligodendrocyte progenitors and ultimately into mature oligodendrocytes. The results of this work may lead to better treatments for multiple sclerosis, characterized by a loss of myelin in brain cells.

Read more: http://bit.ly/1pQJs90
Journal article: Transcription factor induction of human oligodendrocyte progenitor fate and differentiation. PNAS, 2014. doi:10.1073/pnas.1408295111
Image credit: centralasian/Flickr”